Trimethoprim & Combinations:
Contraindications: Neonates. Severe renal or hepatic insufficiency. Blood dyscrasias
Precautions: Pregnancy, lactation, elderly. Renal impairment (reduce or space out dosage). Severe allergy or asthma. Folate or 6-PD deficiency. Perform regular haematological tests during long term therapy. Discontinue if rash develops. Maintain adequate urinary output.
Interactions: Folate inhibitors, anticoagulants, anticonvulsants, hypoglycaemics, cyclosporin, procanamide, amantadine, lamivudine, thiazides, pyrimethamine, digoxin.
Adverse effects: Nausea, vomiting, glossitis, skin rashes. Blood dyscrasias. Folate deficiency. Liver changes. Rarely erythema multiforme, Lyell syndrome, exofoliative dermatitis. Steven-Johnson syndrome, convulsions, peripheral neuritis, ataxia.
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