Aluminum hydroxide and magnesium hydroxide

U.S. BRAND NAMES — Alamag [OTC]; Rulox No. 1 [DSC]; Rulox [OTC]

PHARMACOLOGIC CATEGORY
Antacid

DOSING: ADULTS — Dyspepsia: Oral: 5-10 mL 4-6 times/day, between meals and at bedtime; may be used every hour for severe symptoms

DOSING: ELDERLY — Refer to adult dosing.

DOSING: RENAL IMPAIRMENT — Aluminum and/or magnesium may accumulate in renal impairment.

DOSAGE FORMS — Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Suspension: Aluminum hydroxide 225 mg and magnesium hydroxide 200 mg per 5 mL (360 mL)
Alamag, Rulox: Aluminum hydroxide 225 mg and magnesium hydroxide 200 mg per 5 mL (360 mL)

Tablet, chewable:
Alamag: Aluminum hydroxide 300 mg and magnesium hydroxide 150 mg
Rulox No. 1: Aluminum hydroxide 200 mg and magnesium hydroxide 200 mg [DSC]

DOSAGE FORMS: CONCISE
Suspension: Aluminum hydroxide 225 mg and magnesium hydroxide 200 mg per 5 mL
Alamag [OTC], Rulox [OTC]: Aluminum hydroxide 225 mg and magnesium hydroxide 200 mg per 5 mL

Tablet, chewable:
Alamag [OTC]: Aluminum hydroxide 300 mg and magnesium hydroxide 150 mg

GENERIC EQUIVALENT AVAILABLE — Yes

USE — Antacid, hyperphosphatemia in renal failure

ADVERSE REACTIONS SIGNIFICANT
>10%: Gastrointestinal: Constipation, chalky taste, stomach cramps, fecal impaction

1% to 10%: Gastrointestinal: Nausea, vomiting, discoloration of feces (white speckles)

<1% (Limited to important or life-threatening): Hypomagnesemia, hypophosphatemia

DRUG INTERACTIONS — Decreased effect: Tetracyclines, digoxin, indomethacin, iron salts, isoniazid, allopurinol, benzodiazepines, corticosteroids, penicillamine, phenothiazines, ranitidine, ketoconazole, itraconazole

PREGNANCY RISK FACTOR — C (show table)

DIETARY CONSIDERATIONS — Should be taken 1-3 hours after meals.

CANADIAN BRAND NAMES — Diovol® Ex; Diovol®; Gelusil® Extra Strength; Mylanta™

INTERNATIONAL BRAND NAMES — Diovol (CA); Diovol Ex (CA); Gelusil Extra Strength (CA); Mylanta® (CA)